Table 2.
The GO terms are specifically enriched in skin and hair follicle development, epithelial development and gland development.
| Description | Number | Genes |
|---|---|---|
| Salivary gland morphogenesis and development | 8 | BMP7 DAG1 EGFR FGFR1 LAMA5 NRP1 SNAI2 TGFB3 |
| Branching involved in salivary gland morphogenesis | 6 | BMP7 DAG1 FGFR1 LAMA5 NRP1 SNAI2 |
| mammary gland epithelial cell differentiation | 4 | HIF1A, SMO, PTCH1, LBH |
| Gland development | 42 | ABL1 APOA1 ARHGAP35 ARID5B BMP7 BMPR1A CTNNB1 COBL DAG1 EGFR EZH2 FGFR1 GLI2 GLI3 HIF1A JUN LAMA5 LBH LEF1 LHX3 MKI67 MSN MST1 NRP1 PAX8 PSEN1 PTCH1 RARG RHBDD3 SMAD4 SMO SNAI2 SOCS2 SOSTDC1 SOX9 SP3 SULF2 TAF10 TGFB3 TGFBR2 WLS WNT5A |
| Gland morphogenesis | 20 | BMP7 DAG1 EGFR FBR2 FGFR1 GLI2 GLI3 LAMA5 MKI67 MSN MST1 NRP1 PTCH1 RARG SNAI2 SOSTDC1 SOX9 SULF2 TGFB3 WNT5A |
| Hair follicle development | 14 | APCDD1 CTNNB1 EGFR LAMA5 LGR4 LGR5 LHX2 LRP4 SMAD4 SMO SOSTDC1 SOX9 TNFRSF19 WNT5A |
| Skin development | 33 | ALOX12B APCDD1 ARRDC3 CLDN1 CTNNB1 CYP26B1 DACT2 EGFR ERRFI1 FLNB FOSL2 FRAS1 H2AFY2 LAMA5 LGR4 LGR5 LHX2 LRP4 LTB PSEN1 PTCH2 PTGES3 ROCK1 SMAD4 SMO SOSTDC1 SOX9 TNFRSF19 TGM1 WDR48 WNT16 WNT5A ZFP36L1 |
| Embryonic epithelial tube formation | 23 | ABL1 ARHGAP35 ARID1A BMP7 COBL CTNNB1 HIF1A KDM2B LHX2 LUZP1 OSR1 PAX8 PRICKLE1 PTCH1 PTK7 RARG RGMA SEMA4C SOX9 TMED2 TWIST1 WNT5A ZEB2 |
| Epithelial cell migration | 27 | ADGRA2 APOA1 APOE ARSB EMP2 EFNB2 ETS1 EPHB4 CLASP1 FGFR1 HIF1A ITGB1 JUN KDR KLF4 LOXL2 MYH9 NRP1 PLCG1 RAB25 RHOB S100A2 SOX9 TGFBR2 THBS1 WNT5A ZEB2 |
| Branching morphogenesis of an epithelial tube | 21 | ACVR1 BMP7 CTNNB1 DAG1 DLG5 EDNRA GLI GLI3 LAMA5 LEF1 LGR4 MMP14 NPNT NRP1 PAX8 PTCH1 SMAD4 SMO SOX9 TGFBR2 WNT5A |
| Morphogenesis of a branching epithelium | 24 | ACVR1 BMP7 CTNNB1 DAG1 DLG5 EDNRA FGFR1 GLI2 GLI3 LAMA5 LEF1 LGR4 MMP14 NPNT NRP1 PAX8 PTCH1 RSPO3 SMAD4 SMO SNAI2 SOX9 TGFBR2 WNT5A |
| Morphogenesis of a branching structure | 25 | ACVR1 BMP7 CTNNB1 DAG1 DLG5 EDNRA FGFR1 GLI2 GLI3 LAMA5 LEF1 LGR4 MMP14 NPNT NRP1 PAX8 PRDM1 PTCH1 RSPO3 SMAD4 SMO SNAI2 SOX9 TGFBR2 WNT5A |
| Morphogenesis of an epithelial fold | 8 | BMP7 CTNNB1 EGFR GLI2 HIF1A LUZP1 SOSTDC1 WNT5A |
| Morphogenesis of an epithelial bud | 5 | BMP7 CTNNB1 GLI2 SOSTDC1 WNT5A |
The bold black font represents the downregulated DEGs.