Table 3.
The DEGs enriched in three signaling pathways are potentially related to sweat gland development.
| Signaling Pathway | Number | Genes |
|---|---|---|
| WNT | 19 | CREBBP CTNNB1 EP300 GPC4 JUN LEF1 MAP3K7 NKD1 PRICKLE1 PSEN1 RAC3 RHOA RUVBL1 SMAD4 TP53 WIF1 WNT10B WNT16 WNT5A |
| TGF-beta | 14 | ACVR1 ACVR2A BMP7 BMPR1A CREBBP EP300 RHOA ROCK1 SMAD1 SMAD4 SP1 TGFB3 TGFBR2 THBS1 |
| Hedgehog | 9 | GLI2 GLI3 PTCH1 PTCH2 SHH SMO WNT10B WNT16 WNT5A |
| Hippo | 25 | ACTB ACTG1 BMP7 BMPR1A CCND1 CTNNA1 CTNNB1 FRMD6 GLI2 LEF1 PPP1CB PPP1CC SMAD1 SMAD4 SNAI2 TGFB3 TGFBR2 WNT10B WNT16 WNT5A WWTR1 YWHAE YWHAG YWHAQ YWHAZ |
The bold black font represents the downregulated DEGs.