Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 5;9:1415. doi: 10.1038/s41598-018-38391-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Inhibitory effect of the Qizhu decoction extracts on DEN-induced hepatitis in mice via NF-κB. Mice were given daily injections of DEN (50 mg/kg i.p.) for 28 weeks; some of the mice were only administered DEN (control), whereas others were also intragastrically administered a Qizhu decoction extract (QC) at 20 g/kg of body weight daily throughout the experimental period. (A) Effect of QC on DEN-induced hepatitis detected by H&E staining. (B) Numbers of mice with DEN-induced hepatitis, necrosis, tumor, and liver cancer. (C) The levels of TNF-α (C-1) and IL-1β (C-2) in mouse serum were analyzed by ELISA. Each value indicates the mean ± SD and is representative of results from three independent experiments; ^#P < 0.001 vs. the control (0 QC). (D) The mRNA expression of TNF-α (D-1) and IL-1β (D-2) in mouse livers was determined by real-time PCR, and GAPDH was used as an internal control. Each value indicates the mean ± SD and is representative of results from three independent experiments; ^#P < 0.001 vs. the control (0 QC). (E) The NF-κB activity was analyzed by western blot (E-1), and a corresponding semiquantitative analysis based on optical density was performed using ImageJ software (E-2). The values are presented as the means ± SDs of data from three separate experiments; ^#P < 0.001 vs. the control (0 QC).