Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed mechanism of the role of sEH in the pathogenesis of PD and DLB. Inflammation and ER stress can increase the expression of sEH in the striatum, resulting in enhanced metabolism of anti-inflammatory EpFAs, leading to increased phosphorylation of α-synuclein (Ren et al., 2018). The sEH inhibitors may prevent the progression of aggregation of phosphorylated α-synuclein in the brain.
