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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: J Immunol. 2019 Jan 14;202(4):1153–1162. doi: 10.4049/jimmunol.1801323

FIGURE 6. Anti-DENV2 NS1 antibody titers are associated with protection from DENV2-induced mortality.

FIGURE 6.

Sera from mice immunized with each DENV NS1 serotype in combination with ML-RR-cGAMP/AddaVax were tested by direct ELISA against DENV1 NS1 (A), DENV2 NS1 (B), DENV3 NS1 (C) and DENV4 NS1 (D). These are the same mice evaluated for morbidity and mortality in Figure 4. Mice that did not succumb to DENV2 D220 infection developed significantly higher anti-DENV2 NS1 IgG titers than non-protected mice. Data are representative of 2 independent experiments (protected, n=23; non-protected, n=17; * p<0.05).