Table 1:
Study population characteristics
| Characteristic | Survivors with Thyroid SMN, n (%) (n=118) |
Survivors without Thyroid SMN, n (%) (n=5,206) |
p value |
|---|---|---|---|
| Female | 76 (64.4) | 2,663 (51.2) | 0.004 |
| Type of first cancer | |||
| Leukemia | 32 (27.1) | 1,662 (31.9) | <0.001 |
| CNS | 15 (12.7) | 628 (12.1) | |
| Hodgkin lymphoma | 39 (33.1) | 685 (13.2) | |
| Non-Hodgkin lymphoma | 6 (5.1) | 431 (8.3) | |
| Wilms tumor | 5 (4.2) | 493 (9.5) | |
| Neuroblastoma | 4 (3.4) | 386 (7.4) | |
| Soft tissue sarcoma | 6 (5.1) | 469 (9.0) | |
| Bone cancer | 11 (9.3) | 452 (8.7) | |
| Age at first cancer diagnosis | |||
| <15 years | 96 (81.4) | 4,251 (81.7) | 0.934 |
| ≥15 years | 22 (18.6) | 955 (18.3) | |
| Year of birth | |||
| 1970 or before | 71 (60.2) | 2,373 (45.6) | 0.002 |
| After 1970 | 47 (39.8) | 2,833 (54.4) | |
| Chemotherapy – alkylator | 71 (62.2) | 2,495 (50.9) | 0.016 |
| Radiation | 100 (87.0) | 3,216 (65.1) | <0.001 |
| Radiation to neck | 69 (60.5) | 1,074 (22.2) | <0.001 |
| Thyroid nodules | 91 (83.5) | 523 (10.4) | <0.001 |