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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: J Immunol. 2019 Jan 9;202(4):1033–1038. doi: 10.4049/jimmunol.1801438

Figure 4. RORγt promotes P2X7 receptor expression in HDAC3-deficient DP thymocytes.

Figure 4.

(A) RORγt ChIP-seq snapshot at P2rx7 in WT thymocytes. (B) HDAC3 qChIP at the P2rx7 enhancer in DP thymocytes from WT, HDAC3-cKO, and RORγt -KO Bcl-xl tg mice. Plot shows mean ± SEM of 2–3 mice group. (C) Frequency of P2X7 receptor+ DP thymocytes from OT-II, OT-II HDAC3-cKO, OT-II HDAC3-cKO RORγt-het and OT-II RB3 (OT-II RORγt-KO Bcl-xl HDAC3-cKO) mice. Boxplot depicts 4–5 mice from 4 independent experiments.