Figure 11.

TAC activates corneal cold thermoreceptor endings. A, Representative example of nerve terminal impulses recorded from a mouse corneal ending in control solution, at three different temperatures. B, Recordings from the same ending during application of 30 μm TAC. C, Instantaneous firing frequency from the same ending as in A (control solution), and D, as in B (in TAC). Note the regular firing in bursts during cooling. E, Summary of the effects of 30 μm TAC on spontaneous firing in 7 individual endings at the basal temperature of 34°C. The increase in firing was statistically significant (***p < 0.001, paired Student's t test). F, Mean firing rate in TAC at three different temperatures in 7 cold thermoreceptor endings. Activity at each temperature has been normalized to the value obtained in control solution. Statistical differences evaluated by one-way ANOVA for repeated measures followed by Bonferroni post hoc test. (*p < 0.05, ***p < 0.001.)