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. 2019 Feb 6;39(6):949–969. doi: 10.1523/JNEUROSCI.1726-18.2018

Figure 8.

Figure 8.

TRPM8 antagonists block the excitatory effects of TAC on mice DRG neurons. A, Ratiometric [Ca2+] levels in a fura-2 AM-loaded cultured DRG neuron from a Trpm8BAC-EYFP mouse, showing the response to cold and TAC in control conditions and in the presence of the TRPM8 blocker AMTB (10 μm). B, A similar protocol in the presence of BCTC (50 μm), a different, structurally unrelated, TRPM8 blocker. C, Bar histograms summarizing the effects of AMTB (n = 16), and (D) BCTC (n = 15) on cold- and TAC-evoked responses. Statistical differences evaluated with one-way ANOVA followed by Bonferroni post hoc test. *p < 0.05, ***p < 0.001.