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. 2019 Jan 30;9:22. doi: 10.3389/fonc.2019.00022

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Copyright © 2019 Chuang, Wang, Niu, Zhen, Huang, Hsiao and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Restoration of lamin A and lamin C expressions in lung cancer cells after PF-573228 withdrawal (WD). (A) The senescent cells were released from PF-573228 inhibition for the indicated period. Western blot analysis revealed that the expression levels of lamin A and lamin C were gradually restored in A549 cells and H1299 cells. However, the lamin A and lamin C levels remained lower in H460 cells when senescent H460 cells were incubated in PF-573228-free medium. (B) The expression levels of lamin A and lamin C in A549 cells increased after the cells were released from PF-573228 inhibition. However, H460 cells expressed lower levels of lamin A and lamin C when exposed to PF-573228, and lamin A and lamin C expression in H460 cells remained lower when PF-573228-treated cells were cultured in PF-573228-free medium. Lamin A and lamin C levels in H1299 cells decreased when cells were exposed to PF-573228. After PF-573228 withdrawal, the expression levels of lamin A and lamin C gradually increased in H1299 cells previously treated with PF-573228.