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. 2019 Jan 30;9:22. doi: 10.3389/fonc.2019.00022

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Copyright © 2019 Chuang, Wang, Niu, Zhen, Huang, Hsiao and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disruption of FAK signaling with cellular senescence. Reactivation of FAK signaling was observed in A549 cells in which senescence was induced by 5 days of PF-573228 treatment after PF-573228 withdrawal. (A) The proportion of SA-β-gal-positive A549 cells declined to half when the senescent cells were cultured in PF-573228-free medium. In addition, A549 cells grew exponentially after A549 cells were released from inhibition by 10 μM PF-573228. ^*P < 0.05. (B) The proposed scheme shows that integrin-based signaling activates FAK to trigger cell proliferation, to manage lamin A/C expression to maintain nuclear shape and program anti-senescence. Blockade of FAK signaling by PF-573228 induced cell cycle arrest and senescence.