FIG 2.

Neutralization of BMS-626529 escape mutants with bNAbs. (a) Neutralization of wild-type and mutant ADA pseudotypes by BMS-626529 and bNAbs. The starting concentration of BMS-626529 and each bNAb was 2 nM, followed by serial 2-fold dilutions. The data show the means ± SD of results from three experiments. (b) Calculated IC₅₀ values of ADA Env-pseudotype with escape mutations, normalized to wild-type values, for BMS-626529 and each bNAb. The solid horizontal bars indicate mean fold change in IC₅₀. The data were derived from three independent experiments.