FIG 8.
Synergistic effect between BMS-626529 and NIH45-46G54W against replication-competent HIV-1NL43-ΔR1. (a) Replication of NL43-ΔR1 in the presence of each single agent or the combination of BMS-626529 (0.3 nM) and NIH45-46G54W (0.1 nM). BMS-626529 and bNAb were added every 6 days. These data represent results of two independent experiments performed in duplicate. (b) Comparison of inhibition data corresponding to the expected additive effect and the observed effect during the robust replication phase. The expected additive inhibition effect was calculated for days 3, 6, and 9 based on the effect of each single agent and was compared to that of the combination of both agents. These data represent results of two independent experiments performed in duplicate. Data were analyzed with t tests. **, P < 0.01. (c) Area under the curve (AUC) analysis of data in panel a.