FIG 7.

B cell numbers and γHV68-specific IgM and IgG levels in WT and STING N153S mice. Mice were inoculated intranasally with 2 × 10⁵ PFU of γHV68 and were euthanized 14 days after infection. Splenocytes and pulmonary leukocytes were isolated for flow cytometric analysis. (A and B) Total numbers of CD19⁺ cells in the spleens (A) and lungs (B) of STING N153S and WT mice 14 days after infection with γHV68. (C and D) Virus-specific IgM (C) and IgG (D) in the sera of STING N153S and WT mice 14 days after infection with γHV68. Data represent the means of results for 8 to 9 mice per group, pooled from two independent experiments. Results were analyzed by an unpaired t test. ***, P < 0.001; ****, P < 0.0001.