FIG 1.

ICP27 regulates pUL44 (gC), pUL47, and pUL48 at the transcriptional and translational levels. Schematic representation of the MDV genome depicting the locations of the terminal repeat long (TRL) and short (TRS), internal repeat long (IRL) and short (IRS), and unique long (UL) and short (US) regions. Previous work in other alphaherpesvirus systems showed that ICP27 transcriptionally and translationally regulates pUL44 (gC), pUL47, and pUL48 (16, 29–31). We have shown that these three genes (blue) are dysregulated during MDV replication in cell culture (26–28), leading us to hypothesize that ICP27 is responsible for their dysregulation.