FIG 2.

Immunization with consensus sequence-based antigens elicits immune sera with lower binding to GP than immunization with monovalent homologous vaccines. Groups of five guinea pigs were vaccinated with the indicated vaccine constructs, and sera collected at day 56 were analyzed by ELISA for the ability to bind EBOV GP (A), BDBV GP (B), or SUDV GP (C). The monovalent control sera are from guinea pigs immunized with HPIV3-vectored constructs expressing GP of EBOV (A), BDBV (B), or SUDV (C) from the experiment whose results are shown in Fig. 4. Mean values ± SEM are based on the results for 5 animals per group.