(b) Non-visual symptom

Parameters	Dryness (-)	Dryness (+)	P value∗	Pain (-)	Pain (+)	P value∗	Irritation (-)	Irritation (+)	P value∗
No. of subjects (%)	307	70		359	17		325	51
Age (years)	57.9 ± 14.4	53.8 ± 15.1	0.045∗	57.5 ± 14.6	48.2 ± 14.3	0.018∗	56.9 ± 15.00	58.2 ± 12.58	0.334
% of men	54.7	48.6	0.358	52.9	64.7	0.349	54.7	48.6	0.205
Schirmer test (% ≤ 5 mm)	20.7	11.1	0.488	20.0	0	0.082	25.9	0	0.006∗
MBI (% ≤ 9 s)	8.5	11.6	0.462	8.7	17.6	0.366	7.8	14.5	0.242
Macular GCC (μm), mean	100.6 ± 13.4	105.0 ± 11.5	0.007∗	101.3 ± 13.3	103.3 ± 10.5	0.461	101.4 ± 13.5	101.5 ± 11.3	0.966
FRTWM (μm)	266.1 ± 20.3	265.9 ± 37.5	0.982	265.3 ± 25.0	272.6 ± 30.3	0.526	265.4 ± 26.2	270.4 ± 19.6	0.512

MBI, maximum blinking interval; GCC, thickness of macular ganglion cell complex; FRTWM, full retinal thickness of whole macula.