Table 3.
The multivariable Cox regression for all-cause mortality and prostate cancer-specific mortality among PCa patients and postsurgical dead.
| All-cause mortality | Prostate cancer-specific mortality | |||||
|---|---|---|---|---|---|---|
| Pt. no. | Hazard Ratio (95% CI) | P value | Pt. no. | Hazard Ratio (95% CI) | P value | |
| Age at diagnosis (y) | ||||||
| 30-50 | 292 | 1 (Reference) | NA | 285 | 1 (Reference) | NA |
| 51-70 | 4784 | 2.88 (1.84-4.51) | ∗∗<0.01 | 4487 | 2.16 (1.24-3.77) | ∗∗0.01 |
| 71-85 | 3009 | 7.57 (4.82-11.89) | ∗∗<0.01 | 2662 | 6.09 (3.47-10.69) | ∗∗<0.01 |
| ≥86 | 260 | 23.43 (14.17-38.73) | ∗∗<0.01 | 228 | 17.34 (8.63-34.83) | ∗∗<0.01 |
| Race | ||||||
| White | 6209 | 1 (Reference) | NA | 5649 | 1 (Reference) | NA |
| Black | 1473 | 1.33 (1.17-1.50) | ∗∗<0.01 | 1386 | 1.46 (1.20-1.77) | ∗∗<0.01 |
| Asian | 563 | 0.85 (0.72-1.01) | 0.06 | 529 | 0.81 (0.63-1.05) | 0.11 |
| American Indian | 35 | 2.00 (0.64-6.27) | 0.24 | 34 | 1.25 (0.17-9.05) | 0.82 |
| T | ||||||
| T1 | 2153 | 1 (Reference) | NA | 1954 | 1 (Reference) | NA |
| T2 | 2084 | 0.95 (0.86-1.05) | 0.31 | 1927 | 0.96 (0.82-1.13) | 0.64 |
| T3 | 737 | 0.59 (0.48-0.72) | ∗∗<0.01 | 692 | 0.66 (0.49-0.89) | ∗∗0.01 |
| T4 | 304 | 0.98 (0.76-1.26) | 0.88 | 276 | 0.87 (0.59-1.28) | 0.49 |
| N | ||||||
| N0 | 6409 | 1 (Reference) | NA | 5898 | 1(Reference) | NA |
| N1 | 38 | 2.85 (1.68-4.85) | ∗∗<0.01 | 36 | 5.01 (2.65-9.46) | ∗∗<0.01 |
| N2 | 27 | 1.50 (0.80-2.83) | 0.21 | 25 | 3.10 (1.45-6.65) | ∗∗<0.01 |
| N3 | 5 | 3.82 (1.41-10.32) | ∗∗0.01 | 5 | 2.29 (0.32-16.53) | 0.41 |
| M | ||||||
| M0 | 7424 | NA | NA | 6857 | NA | NA |
| M1 | 672 | NA | NA | 590 | NA | NA |
| Grade | ||||||
| 1 | 317 | 1 (Reference) | NA | 281 | 1 (Reference) | NA |
| 2 | 5249 | 0.79 (0.65-0.96) | ∗0.02 | 4847 | 0.81 (0.60-1.10) | 0.18 |
| 3 | 2209 | 1.20 (0.98-1.48) | 0.08 | 2025 | 1.41 (1.03-1.92) | ∗0.03 |
| 4 | 47 | 2.39 (1.20-4.73) | ∗∗0.01 | 39 | 2.35 (0.83-6.68) | 0.11 |
| Number of localized tumors | ||||||
| 1 | 6475 | 1 (Reference) | NA | 6475 | 1 (Reference) | NA |
| ≥2 | 1870 | 1.88 (1.71-2.06) | ∗∗<0.01 | 1187 | 1.89 (1.62-2.21) | ∗∗<0.01 |
| Location | ||||||
| Localized | 7063 | 1 (Reference) | NA | 652 | 1 (Reference) | NA |
| Invasion | 336 | 2.09 (1.64-2.66) | ∗∗<0.01 | 1 311 | 2.21 (1.54-3.18) | ∗∗<0.01 |
| Metastasis | 687 | 6.48 (3.42-12.30) | ∗∗<0.01 | 606 | 9.52 (4.47-20.24) | ∗∗<0.01 |
| PAP | ||||||
| - | 3161 | 1 (Reference) | NA | 2879 | 1 (Reference) | NA |
| + | 5184 | 1.04 (0.95-1.14) | 0.42 | 4783 | 2.87 (2.48-3.32) | ∗∗<0.01 |
| Surgery | ||||||
| Y | 2760 | 1 (Reference) | NA | 2553 | 1 (Reference) | NA |
| N | 5585 | 1.12 (1.00-1.26) | ∗0.05 | 5109 | 1.09 (0.91-1.30) | 0.36 |
The multivariable Cox regression was performed to identify covariates associated with increased all-cause mortality using the same variables as in the logistic regression model described. In the Cox regression model, enter method was used. Abbreviations: Pt. no.: patient number; y: years; TNM: tumor-node-metastasis; Y: yes; N: no; ∗P ≤ 0.05; ∗∗P ≤ 0.01.