Table 4.
Diagnostic performances of TE, US, and TE combined with US in CHB patients with NAFLD for liver fibrosis and cirrhosis assessment.
| Statistic | TE | US | TE plus US |
|
| |||
| Significant fibrosis assessment (F≥2) | |||
| AUC | 0.84 (0.75, 0.91) | 0.73 (0.63, 0.82) | 0.85 (0.76, 0.92) |
| Standard error | 0.042 | 0.051 | 0.043 |
| Cut-off value | 6.6 | 6 | 0.61 |
| Sensitivity (%) | 78.7 (64.3, 89.3) | 59.6 (44.3, 73.6) | 70.2 (55.1, 82.7) |
| Specificity (%) | 76.6 (62.0, 87.7) | 80.9 (66.7, 90.9) | 95.7 (85.5, 99.5) |
| PPV (%) | 77.1 (62.7, 88.0) | 75.7 (58.8, 88.2) | 94.3 (80.8, 99.3) |
| NPV (%) | 78.3 (63.6, 89.1) | 66.7 (52.9, 78.6) | 76.3 (63.4, 86.4) |
| Positive LR | 3.36 (2.0, 5.8) | 3.11 (1.7, 5.9) | 16.50 (4.2, 64.9) |
| Negative LR | 0.28 (0.2, 0.5) | 0.50 (0.3, 0.7) | 0.31 (0.2, 0.5) |
| Advanced fibrosis assessment (F≥3) | |||
| AUC | 0.95 (0.89, 0.98) | 0.76 (0.66, 0.84) | 0.95 (0.89, 0.99) |
| Standard error | 0.024 | 0.052 | 0.026 |
| Cut-off value | 8.7 | 6 | 0.39 |
| Sensitivity (%) | 83.9 (66.3, 94.5) | 67.7 (48.6, 83.3) | 87.1 (70.2, 96.4) |
| Specificity (%) | 96.8 (89.0, 99.6) | 74.6 (62.1, 84.7) | 95.2 (86.7, 99.0) |
| PPV (%) | 92.9 (76.5, 99.1) | 56.8 (39.5, 72.9) | 90.0 (73.5, 97.9) |
| NPV (%) | 92.4 (83.2, 97.5) | 82.5 (70.1, 91.3) | 93.7 (84.8, 98.3) |
| Positive LR | 26.4 (6.7, 104.2) | 2.7 (1.6, 4.3) | 18.3 (6.0, 55.6) |
| Negative LR | 0.17 (0.07, 0.4) | 0.43 (0.3, 0.7) | 0.14 (0.05, 0.3) |
| Cirrhosis assessment (F=4) | |||
| AUC | 0.96 (0.90, 0.99) | 0.71 (0.61, 0.80) | 0.96 (0.90, 0.99) |
| Standard error | 0.023 | 0.071 | 0.022 |
| Cut-off value | 10.9 | 7 | 0.14 |
| Sensitivity (%) | 92.9 (66.1, 99.8) | 50.0 (23.0, 77.0) | 92.9 (66.1, 99.8) |
| Specificity (%) | 93.8 (86.0, 97.9) | 85.0 (75.3, 92.0) | 93.8 (86.0, 97.9) |
| PPV (%) | 72.2 (46.5, 90.3) | 36.8 (16.3, 61.6) | 72.2 (46.5, 90.3) |
| NPV (%) | 98.7 (92.9, 100.0) | 90.7 (81.7, 96.2) | 98.7 (92.9, 100.0) |
| Positive LR | 14.9 (6.3, 35.1) | 3.3 (1.6, 7.0) | 14.9 (6.3, 35.1 ) |
| Negative LR | 0.08 (0.01, 0.5) | 0.59 (0.3, 1.0) | 0.08 (0.01, 0.5) |
Data in parentheses were 95% confidence interval. AUC=area under the ROC curve. PPV=positive predictive value. NPV=negative predictive value. LR=likelihood ratio.