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. 2018 Dec 19;17(3):1697–1705. doi: 10.3892/etm.2018.7112

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — PTEN is a direct target of miR-183. (A) The 3′-UTR of PTEN mRNA was observed to contain a sequence complementary to miR-183, using miRanda. (B) Overexpression of miR-183 significantly suppressed the luciferase activity of reporters containing the WT 3′-UTR of PTEN, but not of the reporters containing the mutant-type MT 3′-UTR of PTEN. *P<0.05 vs. NC. PTEN, phosphatase and tensin homolog deleted on chromosome ten; miR, microRNA; UTR, untranslated region; WT, wild type; MT, mutant type; luc/R-luc, luciferase/Renilla luciferase; NC, inhibitor control transfected group, Control, untransfected group.