Table III.
Genotypic and allelic frequencies of receptor for advanced glycation end products polymorphisms in the control (n=867) and CAD group (n=852).
| Polymorphism | Genotypes/alleles | Control | Patients with CAD | P-value | OR (95% CI) |
|---|---|---|---|---|---|
| Rs10754558 | Genotypes | ||||
| CC | 229 (26.4) | 265 (31.1) | 1.00 | ||
| CG | 459 (52.9) | 439 (51.5) | 0.089 | 0.826 (0.663–1.030) | |
| GG | 179 (20.6) | 148 (17.4) | 0.019 | 0.714 (0.540–0.946) | |
| Alleles | |||||
| C | 917 (52.9) | 969 (56.9) | 1.00 | ||
| G | 817 (47.1) | 735 (43.1) | 0.019 | 0.851 (0.744–0.974) | |
| Rs10925025 | Genotypes | ||||
| AA | 156 (18.0) | 156 (18.3) | 1.00 | ||
| AG | 455 (52.5) | 405 (47.5) | 0.379 | 0.890 (0687–1.153) | |
| GG | 256 (29.5) | 291 (34.2) | 0.367 | 1.137 (0.861–1.501) | |
| Alleles | |||||
| A | 767 (44.2) | 717 (42.1) | 1.00 | ||
| G | 967 (55.8) | 987 (57.9) | 0.202 | 1.091 (0.953–1.249) | |
| Rs12048215 | Genotypes | ||||
| AA | 477 (54.9) | 456 (53.5) | 1.00 | ||
| AG | 344 (39.6) | 354 (41.5) | 0.462 | 1.076 (0.885–1.310) | |
| GG | 46 (5.5) | 42 (4.9) | 0.955 | 0.955 (0.617–1.479) | |
| Alleles | |||||
| A | 1,298 (74.9) | 1,266 (74.3) | 0.019 | 0.844 (0.733–0.973) | |
| G | 436 (25.1) | 438 (25.7) | |||
| Rs12143966 | Genotypes | ||||
| AA | 177 (20.4) | 201 (23.6) | 1.00 | ||
| AG | 204 (23.5) | 211 (24.7) | 0.837 | 0.955 (0.617–1.479) | |
| GG | 486 (56.1) | 440 (51.6) | 0.064 | 0.797 (0.627–1.013) | |
| Alleles | |||||
| A | 558 (32.2) | 613 (35.9) | 1.00 | ||
| G | 1,176 (67.8) | 1,091 (64.0) | 0.091 | 0.827 (0.718–0.953) | |
| Rs12564791 | Genotypes | ||||
| CC | 633 (73.0) | 639 (75.0) | 1.00 | ||
| CT | 222 (25.6) | 189 (22.2) | 0.134 | 0.843 (0.675–11.054 | |
| TT | 12 (1.4) | 24 (2.8) | 0.052 | 1.981 (0.982–3.996) | |
| Alleles | |||||
| C | 1,488 (85.8) | 1,467 (86.1) | 0.814 | 0.977 (0.806–1.185) | |
| T | 246 (14.2) | 237 (13.9) | |||
| Rs1800624 | Genotypes | ||||
| AA | 588 (67.8) | 594 (69.7) | 1.00 | ||
| AT | 261 (30.1) | 234 (27.5) | 0.265 | 0.887 (0.719–1.095) | |
| TT | 18 (2.1) | 24 (2.8) | 0.380 | 1.320 (0.709–2.456) | |
| Alleles | |||||
| A | 1,437 (82.9) | 1,422 (83.5) | 0.682 | 0.960 (0.802–1.147) | |
| T | 297 (17.1) | 237 (16.5) | |||
| Rs2027432 | Genotypes | ||||
| GG | 747 (86.2) | 732 (85.9) | 1.00 | ||
| AG | 117 (13.5) | 111 (13.0) | 0.820 | 0.968 (0.732–1.280) | |
| AA | 3 (0.3) | 9 (1.1) | 0.078 | 3.061 (0.826–11.353) | |
| Alleles | |||||
| A | 123 (7.1) | 129 (7.6) | |||
| G | 1,611 (92.9) | 1,575 (92.4) | 0.601 | 0.932 (0.721–1.205) | |
| Rs204993 | Genotypes | ||||
| AA | 312 (36.0) | 294 (34.5) | 1.00 | ||
| AG | 435 (50.2) | 408 (47.9) | 0.965 | 0.995 (0.808–1.227) | |
| GG | 120 (13.8) | 150 (17.6) | 0.054 | 1.327 (0.994–1.769) | |
| Alleles | |||||
| A | 123 (7.1) | 129 (7.6) | 1.00 | ||
| G | 1,611 (92.9) | 1,575 (92.4) | 0.118 | 1.115 (0.973–1.278) | |
| Rs204994 | Genotypes | ||||
| CC | 554 (63.9) | 528 (62.0) | 1.00 | ||
| CT | 289 (33.3) | 288 (33.8) | 0.665 | 1.046 (0.854–1.280) | |
| TT | 24 (2.8) | 36 (4.2) | 0.091 | 1.574 (0.926–2.674) | |
| Alleles | |||||
| C | 1,397 (80.5) | 1,344 (78.9) | 1.00 | ||
| T | 337 (19.4) | 360 (21.1) | 0.710 | 1.110 (0.637–1.322) | |
| Rs2269421 | Genotypes | ||||
| CC | 809 (93.2) | 816 (95.8) | 1.00 | ||
| CG | 55 (6.5) | 33 (3.8) | 0.020 | 0.595 (0.382–0.926) | |
| GG | 3 (0.3) | 3 (0.4) | 0.990 | 0.991 (0.200–4.927) | |
| Alleles | |||||
| C | 1,674 (96.4) | 1,685 (97.7) | 1.00 | ||
| T | 62 (3.6) | 39 (2.3) | 0.026 | 0.625 (0.416–0.938) | |
| Rs2071290 | Genotypes | ||||
| CC | 804 (92.7) | 798 (93.7) | 1.00 | ||
| CT | 63 (7.3) | 51 (6.0) | 0.295 | 0.816 (0.557–1.195) | |
| TT | 0 (0.0) | 3 (0.4) | 0.082 | 1.004 (1.000–1.008) | |
| Alleles | |||||
| C | 1,674 (96.4) | 1,685 (97.7) | 1.00 | ||
| G | 62 (3.6) | 39 (2.3) | 0.710 | 0.918 (0.637–1.322) | |
| Rs2269422 | Genotypes | ||||
| TT | 723 (83.4) | 598 (70.2) | 1.00 | ||
| AT | 138 (15.9) | 239 (28.1) | <0.001 | 2.094 (1.654–2.651 | |
| AA | 6 (0.7) | 15 (1.8) | 0.017 | 3.023 (1.166–7.838) | |
| Alleles | |||||
| A | 150 (8.7) | 269 (15.8) | <0.001 | 0.505 (0.409–0.625) | |
| T | 1,584 (91.3) | 1,435 (84.2) | |||
| Rs2269423 | Genotypes | ||||
| AA | 78 (9.0) | 81 (9.5) | 1.00 | ||
| AC | 351 (40.5) | 363 (42.6) | 0.981 | 0.996 (0.706–1.404) | |
| CC | 438 (50.5) | 408 (47.9) | 0.530 | 0.897 (0.639–1.259) | |
| Alleles | |||||
| A | 507 (29.2) | 525 (30.8) | 1.00 | ||
| T | 1,277 (70.8) | 1,179 (69.2) | 0.315 | 0.928 (0.802–1.074) | |
| Rs300647 | Genotypes | ||||
| CC | 693 (79.9) | 687 (80.6) | 1.00 | ||
| AC | 168 (19.4) | 165 (19.4) | 0.016 | 0.991 (0.780–1.259 | |
| AA | 6 (0.7) | 0 (0.0) | 0.015 | 0.991 (0.985–0.998) | |
| Alleles | |||||
| A | 180 (79.8) | 165 (9.7) | 1.00 | ||
| C | 1,554 (20.2) | 1,539 (90.3) | 1.080 | 0.532 (0.799–1.251) | |
| Rs2282659 | Genotypes | ||||
| AA | 552 (63.7) | 514 (60.3) | 1.00 | ||
| AG | 279 (32.2) | 301 (35.3) | 0.154 | 1.159 (0.949–1.419) | |
| GG | 36 (4.2) | 37 (4.3) | 0.683 | 1.104 (0.687–1.774) | |
| Alleles | |||||
| A | 1,383 (79.8) | 1,329 (78.0) | 1.00 | ||
| G | 351 (20.2) | 375 (22.0) | 0.210 | 1.113 (0.944–1.311) | |
| Rs3014880 | Genotypes | ||||
| CC | 702 (81.0) | 684 (80.3) | 1.00 | ||
| CG | 159 (18.3) | 168 (19.7) | 0.510 | 1.084 (0.852–1.380) | |
| GG | 6 (0.7) | 0 (0.0) | 0.016 | 0.992 (0.985–0.998) | |
| Alleles | |||||
| C | 1,563 (90.1) | 1,329 (78.0) | 1.00 | ||
| G | 171 (9.9) | 375 (22.0) | 0.042 | 1.000 (0.799–1251) | |
| Rs3014885 | Genotypes | ||||
| CC | 690 (79.6) | 681 (79.9) | 1.00 | ||
| CT | 171 (19.7) | 171 (20.1) | 0.914 | 1.013 (0.799–1,284) | |
| TT | 6 (0.7) | 0 (0.0) | 0.015 | 0.991 (0.985–0.998) | |
| Alleles | |||||
| C | 1,551 (89.4) | 1,533 (90.0) | 1.00 | ||
| T | 183 (10.6) | 171 (10.0) | 0.998 | 0.933 (0.749–1.163) | |
| Rs3130349 | Genotypes | ||||
| TT | 645 (74.4) | 624 (73.2) | 1.00 | ||
| CT | 216 (24.9) | 213 (25.0) | 0.864 | 1.019 (0.890–1.269) | |
| CC | 6 (0.7) | 15 (1.8) | 0.043 | 2.584 (0.996–6.073) | |
| Alleles | |||||
| C | 228 (13.1) | 243 (14.3) | 1.00 | ||
| T | 1,506 (86.9) | 1,461 (85.7) | 0.129 | 0.910 (0.749–1.106) | |
| Rs3134943 | Genotypes | ||||
| CC | 699 (80.6) | 663 (77.8) | 1.00 | ||
| CT | 153(17.6) | 171 (20.1) | 0.185 | 1.178 (0.924–1.502) | |
| TT | 15 (1.7) | 18 (20.1) | 0.505 | 1.265 (0.632–0.531) | |
| Alleles | |||||
| C | 1,551 (89.4) | 1,497 (87.9) | 1.00 | ||
| T | 183 (10.6) | 207 (12.1) | 0.346 | 1.172 (0.949–1.448) | |
| Rs3134946 | Genotypes | ||||
| CC | 684 (78.9) | 663 (77.8) | 1.00 | ||
| CG | 177 (20.4) | 171 (20.1) | 0.978 | 0.997 (0.787–1.262) | |
| GG | 6 (0.7) | 18 (20.1) | 0.012 | 3.095 (1.221–7.885) | |
| Alleles | |||||
| C | 1,545 (89.4) | 1,505 (88.3) | 1.00 | ||
| G | 189 (10.6) | 199 (11.7) | 0.484 | 1.081 (0.875–1.335) | |
| Rs3738448 | Genotypes | ||||
| GG | 558 (64.5) | 574 (67.4) | 1.00 | ||
| CT | 264 (30.4) | 241 (28.3) | 0.265 | 0.887 (0.719–1.095) | |
| TT | 45 (5.2) | 37 (4.3) | 0.329 | 0.799 (0.570–1.254) | |
| Alleles | |||||
| G | 1,380 (79.6) | 1,389 (81.5) | 0.155 | 0.884 (0.747–1.047) | |
| T | 354 (20.4) | 315 (18.5) | |||
| Rs4772 | Genotypes | ||||
| AA | 693 (79.9) | 690 (81.0) | 1.00 | ||
| G | 168 (19.4) | 159 (18.7) | 0.680 | 0.951 (0.747–1.210) | |
| GG | 6 (0.7) | 3 (0.3) | 0.322 | 0.502 (0.125–2.016) | |
| Alleles | |||||
| A | 1,544 (89.6) | 1,539 (90.3) | 1.00 | ||
| G | 180 (10.4) | 165 (9.7) | 0.532 | 1.767 (1.452–2.150) | |
| Rs4925648 | Genotypes | ||||
| CC | 576 (64.4) | 570 (66.9) | 1.00 | ||
| CT | 267 (30.8) | 246 (28.9) | 0.501 | 0.931 (0.756–1.147) | |
| TT | 24 (2.8) | 36 (4.2) | 0.121 | 1.516 (0.893–2.573) | |
| Alleles | |||||
| A | 1,419 (81.8) | 1,386 (81.3) | 1.00 | ||
| T | 315 (18.2) | 318 (18.7) | 0.708 | 1.034 (0.870–1.228) | |
| Rs7528887 | Genotypes | ||||
| AA | 465 (53.6) | 450 (52.8) | 1.00 | ||
| AG | 330 (38.0) | 351 (41.2) | 0.351 | 1.099 (0.901–1.340) | |
| GG | 72 (8.3) | 51 (6.0) | 0.108 | 0.732 (0.500–1.072) | |
| Alleles | |||||
| A | 1,260 (72.7) | 1,251 (73.4) | 1.00 | ||
| G | 474 (27.3) | 453 (26.6) | 0.963 | 0.963 (0.828–1.119) | |
| Rs7529058 | Genotypes | ||||
| CC | 234 (27.0) | 228 (26.8) | 1.00 | ||
| CG | 407 (46.9) | 390 (45.8) | 0.887 | 0.983 (0.782–1.237) | |
| GG | 226 (26.1) | 234 (27.5) | 0.645 | 1.063 (0.821–1.376) | |
| Alleles | |||||
| C | 875 (50.5) | 846 (49.6) | 1.00 | ||
| G | 859 (49.5) | 858 (50.4) | 0.657 | 1.033 (0.904–1.181) |
OR, odds ratio; CI, confidence interval; CAD, coronary artery disease.