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. 2018 Dec 21;17(3):1841–1846. doi: 10.3892/etm.2018.7126

Figure 2.

Figure 2.

Rab3D is a direct target of miR-761 in CRC. (A) A schematic description of the base-pairing interaction between miR-761 and 3′-UTR of Rab3D. (B) miR-761 overexpression significantly decreased luciferase activity of wt Rab3D 3′-UTR but not mut Rab3D 3′-UTR. (C) Western blotting to analyze Rab3D expression in CRC tissues and nontumor tissues. (D) Correlation analysis was performed for miR-761 and Rab3D expression in CRC tissues. (E) Western blotting to analyze Rab3D expression in the SW480 cell line with the miR-mimic or NC transfection. ***P<0.001 vs. the wt NC. ns vs. the wt NC group. miR-761, microRNA-761; ns, not significant; CRC, colorectal cancer; UTR, untranslated region; wt, wild-type; mut, mutant; NC, negative control.