Table 1. Time Optimization Dataa.
| time point (h) | tumor tracer uptake (%ID/g) | tumor-to-muscle | tumor-to-blood | |
|---|---|---|---|---|
| nonblocked | 4 | 3.0 ± 1.5 | 6.2 ± 2.2 | 1.1 ± 0.4 |
| 24 | 3.0 ± 1.8 | 8.7 ± 1.9 | 19 ± 15 | |
| 48 | 1.7 ± 0.8 | 7.6 ± 4.5 | 24 ± 13 | |
| blocked | 4 | 1.5 ± 0.5 | 2.8 ± 0.7 | 0.5 ± 0.1 |
| 24 | 1.1 ± 0.3 | 2.9 ± 0.4 | 5.8 ± 1.3 | |
| 48 | 0.6 ± 0.1 | 3.8 ± 1.8 | 8.0 ± 1.0 |
a
Time optimization experiment of 111In-girentuximab-F(ab′)2 performed on mice baring SCCNij153 tumors. Specific binding was blocked by preinjecting an excess amount of unlabeled girentuximab IgG.