Table 5. Inclusion and exclusion criteria for the longitudinal cohorts for the DOLORisk protocol.

	Inclusion criteria	Exclusion criteria
Chemotherapy	•   ≥18 years. •   Diagnosed with high-risk colorectal cancer. •   Planned adjuvant treatment with oxaliplatin and     flourouracil (5-FU) or capecitabine (Pro 5-FU).	•   Known metastatic cancer. •   Previous treatment with chemotherapy. •   Significant mental illness. •   Alcohol abuse. •   Known diabetes. •   Significant neuropathic diseases. •   Spinal cord stenosis. •   Peripheral vascular diseases (Fontaine >2). •   Chronic pain with a pain intensity on a 0-10 numeric     rating scale >5. •   Patients who do not speak, read or understand Danish.
Thoracotomy	•   ≥ 18 years. •   Scheduled for lung cancer resection performed     via thoracoscopy and/or thoracotomy, including     lobectomy, bilobectomy, pneumonectomy,     resection of the tracheobronchial bifurcation,     wedge resection, sleeve resection and     combinations hereof. •   Willingness and ability to comply with study     procedures as judged by the site investigator/     manager. •   Expected availability for follow-up throughout the     study.	•   Mental incapacity or language barriers precluding     adequate understanding of study procedures. •   Current alcohol or substance abuse according to the     site investigator’s medical judgement. •   Unsuitability for participation in the study for any other     reason, e.g. due to a significant serious underlying     condition (e.g. other cancer or AIDS), as determined by     the site investigator/manager.     ADDITIONALLY in FR: •   Previous surgery on the same area. •   Surgery targeting only the pleura or mediastinum. •   Peripheral neurological pathology or central (brain     damage, multiple sclerosis) susceptible to interfere with     the evaluation of the post-operative pain. •   History of significant mental illness: psychosis, severe     depression having motivated a hospitalisation, suicide     attempt. •   Current major depressive episode at the time of the     evaluation. •   Abuse of drug or psychoactive substance during the last     six months. •   Patients participating in another protocol of biomedical     research.
Mastectomy	•   Women ≥ 18 years. •   Scheduled for breast cancer resection performed     via lumpectomy (partial or segmental mastectomy)     or mastectomy with or without sentinel lymph node     biopsy and axillary lymph node dissection, and     any combinations hereof. •   Affiliated to a social security scheme. •   Danish/French language (read, written and     spoken). •   Willingness and ability to comply with study     procedures as judged by the site investigator. •   Expected availability for follow-up throughout the     study.	•   Cognitive or psychological disorders incompatible with     the respect and/or the understanding of the protocol. •   Current alcohol or substance abuse according to the site     investigator's medical judgement. •   Unsuitability for participation in the study for any other     reason, e.g. due to a significant serious underlying     condition (e.g. other cancer or AIDS), as determined by     the site investigator. •   Previous surgery on the same area. •   Peripheral neurological pathology or central (brain     damage, multiple sclerosis) susceptible to interfere with     the evaluation of the post-operative pain. •   History of significant mental illness: psychosis, severe     depression having motivated a hospitalisation, suicide     attempt. •   Current major depressive episode at the time of     assessment. •   Abuse of drug or psychoactive substance during the last     six months •   Participating in another protocol of biomedical research. •   Other cancer or AIDS. •   Scheduled for bilateral mastectomy. •   Presence of chronic pain before the breast cancer     surgery. •   Workplace accident, litigation or search for     compensation.