Table 5.
Clinical characteristics of TM6SF2 rs58542926 T carriers and non-carriers in each groupa
| NAFLD | NAFLD&CRA | |||||
| Carriers (n = 13) |
Non-carriers (n = 188) |
P value | Carriers (n = 13) |
Non-carriers (n = 175) |
P value | |
| Age (yr) | 53.80 ± 0.46 | 55.00 ± 0.51 | 0.534 | 54.90 ± 0.61 | 54.30 ± 0.49 | 0.411 |
| BMI (kg/m2) | 24.99 ± 1.36 | 23.95 ± 1.23 | 0.957 | 24.98 ± 1.98 | 26.12 ± 2.02 | 0.053 |
| CAP (dB/m) | 262.34 ± 32.65 | 239.11 ± 37.76 | 0.031 | 260.21 ± 22.52 | 240.46 ± 21.34 | 0.001 |
| FPG (mmol/L) | 4.89 ± 0.98 | 5.13 ± 0.12 | 0.163 | 5.21 ± 0.32 | 5.26 ± 0.79 | 0.341 |
| TC (mmol/L) | 5.01 ± 0.67 | 5.63 ± 0.83 | 0.352 | 4.80 ± 0.98 | 5.61 ± 0.78 | 0.013 |
| TG (mmol/L) | 1.49 ± 1.21 | 2.09 ± 0.95 | 0.031 | 1.50 ± 1.39 | 2.12 ± 1.09 | 0.001 |
| LDL-C (mmol/L) | 3.38 ± 0.37 | 3.29 ± 0.41 | 0.571 | 3.12 ± 0.62 | 3.36 ± 0.70 | 0.039 |
| HDL-C (mmol/L) | 1.39 ± 0.43 | 1.24 ± 0.12 | 0.368 | 1.30 ± 0.32 | 1.35 ± 0.37 | 0.276 |
| AST (U/L) | 44.40 ± 7.90 | 37.30 ± 7.60 | 0.067 | 46.30 ± 8.90 | 38.70 ± 8.70 | 0.048 |
| ALT (U/L) | 43.70 ± 8.90 | 35.76 ± 9.10 | 0.039 | 45.80 ± 10.40 | 37.80 ± 9.40 | 0.043 |
| UA (μmol/L) | 363.34 ± 81.36 | 373.43 ± 78.02 | 0.632 | 372.51 ± 70.91 | 367.48 ± 61.32 | 0.652 |
| CRA | Control | |||||
| Carriers (n = 7) |
Non-carriers (n = 204) |
P value | Carriers (n = 5) |
Non-carriers (n = 234) |
P value | |
| Age (yr) | 55.90 ± 0.54 | 54.90 ± 0.48 | 0.853 | 53.80 ± 0.57 | 54.20 ± 0.65 | 0.967 |
| BMI (kg/m2) | 24.38 ± 1.38 | 23.85 ± 1.56 | 0.574 | 22.98 ± 0.91 | 23.13 ± 0.77 | 0.968 |
| CAP (dB/m) | 240.66 ± 34.73 | 227.66 ± 30.67 | 0.195 | 210.45 ± 30.67 | 199.48 ± 25.76 | 0.698 |
| FPG (mmol/L) | 5.04 ± 0.45 | 4.79 ± 0.71 | 0.837 | 4.99 ± 1.03 | 4.69 ± 0.68 | 0.753 |
| TC (mmol/L) | 5.29 ± 0.98 | 5.54 ± 0.63 | 0.111 | 5.27 ± 0.76 | 5.74 ± 0.64 | 0.386 |
| TG (mmol/L) | 1.76 ± 1.28 | 1.92 ± 1.37 | 0.093 | 1.36 ± 0.98 | 1.57 ± 1.21 | 0.215 |
| LDL-C (mmol/L) | 3.23 ± 0.75 | 3.30 ± 0.63 | 0.265 | 2.92 ± 0.97 | 3.31 ± 0.67 | 0.470 |
| HDL-C (mmol/L) | 1.47 ± 0.63 | 1.33 ± 0.59 | 0.097 | 1.57 ± 0.31 | 1.31 ± 0.54 | 0.865 |
| AST (U/L) | 36.90 ± 10.80 | 33.50 ± 7.50 | 0.683 | 30.60 ± 6.30 | 32.70 ± 7.70 | 0.461 |
| ALT (U/L) | 30.60 ± 9.90 | 32.80 ± 13.10 | 0.473 | 26.90 ± 8.10 | 32.90 ± 10.30 | 0.643 |
| UA (μmol/L) | 358.61 ± 81.53 | 379.61 ± 84.98 | 0.352 | 335.36 ± 67.69 | 351.55 ± 73.64 | 0.198 |
Abbreviations: NAFLD non-alcoholic fatty liver disease, CRA colorectal adenoma, BMI body mass index, CAP controlled attenuation parameter, FPG fasting plasma glucose, TC total cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, AST aspartate aminotransferase, ALT alanine aminotransferase, UA uric acid
aValues are expressed as mean ± SD and compared by Student’s t-test