Table 6.
Clinical characteristics of TM6SF2 rs58542926 T carriers and non-carriers in overall subjectsa
| Characteristic | CC (n = 794) | CT + TT (n = 45) | P Value |
|---|---|---|---|
| Age (yr) | 54.60 ± 0.49 | 54.70 ± 0.48 | 0.863 |
| BMI (kg/m2) | 24.26 ± 1.40 | 24.33 ± 1.41 | 0.841 |
| CAP (dB/m) | 226.68 ± 28.88 | 243.42 ± 30.14 | 0.034 |
| FPG (mmol/L) | 4.97 ± 0.58 | 5.03 ± 0.81 | 0.741 |
| TC (mmol/L) | 5.63 ± 0.72 | 5.09 ± 0.85 | 0.175 |
| TG (mmol/L) | 1.93 ± 1.15 | 1.53 ± 1.22 | 0.029 |
| LDL-C (mmol/L) | 3.32 ± 0.60 | 3.16 ± 0.68 | 0.492 |
| HDL-C (mmol/L) | 1.31 ± 0.41 | 1.43 ± 0.42 | 0.429 |
| AST (U/L) | 39.66 ± 8.50 | 43.93 ± 7.90 | 0.042 |
| ALT (U/L) | 34.82 ± 10.50 | 36.57 ± 9.30 | 0.093 |
| UA (μmol/L) | 368.03 ± 74.49 | 357.46 ± 75.37 | 0.735 |
Abbreviations: NAFLD non-alcoholic fatty liver disease, CRA colorectal adenoma, BMI body mass index, CAP controlled attenuation parameter, FPG fasting plasma glucose, TC total cholesterol, TG triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, AST aspartate aminotransferase, ALT alanine aminotransferase, UA uric acid
aValues are expressed as mean ± SD and compared by Student’s t-test