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. 2019 Feb 6;19:27. doi: 10.1186/s12935-019-0742-0

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Target gene prediction and function analysis. a The common genes targeted by the three miRNAs as predicted by DIANA, miRDB, and TargetScan. b Biological process analysis (upper left) indicated that the genes are associated with cell–cell adhesion, signal transduction, negative regulation of cell proliferation, regulation of focal adhesion assembly, wound healing, and cell migration. Cellular component analysis (upper right) showed that the genes are associated with cell–cell adherent junctions, membranes, focal adhesion, cytosol, and microtubules. Molecular function analysis (lower left) indicated that the genes are involved in metal ion binding, cadherin binding cell–cell adhesion, and beta-catenin binding. Biological pathway analysis (lower right) revealed that the genes participate in PI3K-Akt, MAPK, and Ras signaling pathways