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. 2019 Feb 6;20:26. doi: 10.1186/s12931-019-0988-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — M2 macrophages induce the differentiation of CD4 + CD25 + Foxp3+ T cells (Tregs) via the TGF-β/Smad signalling pathway. a. Percentage of Tregs in different groups (blank control, supernatant of M1 cells, M1 cells, supernatant of M2 cells and M2 cells). b. Concentration of TGF-β1 in monocyte-derived M2 macrophages before and after coculture. c. Western blot analysis of TGF-β/Smad signalling pathway in monocyte-derived M2 macrophages. d. The proportion of Tregs decreased compared with that in the untreated group after addition of LY2109761. *P < 0.05, ***P < 0.001