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. 2019 Feb 6;17:25. doi: 10.1186/s12951-019-0457-3

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The characteristics of the drug/LPPC/targeting antibody complex. a The scheme for curcumin/LPPC/Herceptin preparation. PEI provides its positive charges of amine groups interact with the carboxy groups of antibodies. b The maximal-binding capacity of Herceptin to LPPC. LPPC (40 μg) was incubated with different amounts of Herceptin, and the maximal amount of bound protein was analyzed with the Bradford Assay. c The particle size and d zeta-potential of the drug/LPPC/targeting antibodies complex. e The effect of Herceptin association on curcumin release from the curcumin/LPPC complexes. Curcumin/LPPC or Curcumin/LPPC/Herceptin complexes were incubated in PBS at 4, 25 or 37 °C. As previous described in the materials and methods section, the concentration of curcumin in each supernatant was measured at various incubation time points and compared with the total curcumin concentration. All values represent the mean ± SD, ***p < 0.001 (n = 3)