Table 2.
Electrolyte serum concentrations and 24-hour creatinine-normalized urine excretion at baseline and week 4 in patients with baseline serum phosphate >4.8 mg/dl (hyperphosphatemia) and baseline serum phosphate ≤4.8 mg/dl
| Parameter | Baseline | Week 4 | Change from Baseline to Week 4 | |||
|---|---|---|---|---|---|---|
| Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | |
| Patients with baseline serum phosphate >4.8 mg/dl | ||||||
| Serum electrolytes, mg/dl | ||||||
| Calciuma | 9.1 (0.5) | 16 | 9.3 (0.3) | 13 | 0.1 (0.4) | 13 |
| Magnesium | 2.3 (0.4) | 16 | 2.1 (0.4) | 13 | −0.1 (0.1) | 13 |
| Phosphate | 5.3 (0.4) | 16 | 4.7 (0.9) | 13 | −0.6 (0.8) | 13 |
| 24-h creatinine-normalized urine electrolytes, mg/24 h | ||||||
| Calcium | 30.5 (19.9) | 6 | 32.3 (20.0) | 6 | 1.8 (12.3) | 6 |
| Phosphate | 722.8 (331.9) | 9 | 573.7 (304.7) | 9 | −149.1 (162.6) | 9 |
| Patients with baseline serum phosphate ≤4.8 mg/dl | ||||||
| Serum electrolytes, mg/dl | ||||||
| Calciuma | 9.4 (0.6) | 95 | 9.5 (0.6) | 87 | 0.0 (0.5) | 87 |
| Magnesium | 2.1 (0.3) | 95 | 2.0 (0.3) | 87 | −0.2 (0.2) | 87 |
| Phosphate | 3.9 (0.6) | 95 | 3.9 (0.6) | 87 | 0.0 (0.6) | 87 |
| 24-h creatinine-normalized urine electrolytes, mg/24 h | ||||||
| Calcium | 52.7 (56.9) | 67 | 60.7 (61.2) | 72 | 9.3 (44.6) | 63 |
| Phosphate | 604.8 (277.5) | 94 | 573.6 (286.1) | 86 | −49.9 (194.4) | 86 |
a
Serum albumin-corrected calcium performed according to the following: if serum albumin ≥4.0 g/dl, corrected calcium=serum calcium; if serum albumin <4.0 g/dl, corrected calcium=serum calcium+(0.8×[4−serum albumin]). For calculations, calcium units were milligrams per deciliter and albumin units were grams per deciliter.