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. Author manuscript; available in PMC: 2020 Feb 15.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Dec 22;29(4):619–622. doi: 10.1016/j.bmcl.2018.12.048

Table 1.

Effect of 8-methoxypsoralen derivatives on keratinocyte growth*:

Cpd R-group  Purity# & Physical
Aspect
mp (°C)		 [A] IC50 with
UVA light
(30 min
contact)		 [B] IC50 w/o
UVA light
(30 min
contact)		 [C] IC50 w/o
UVA
(5 day
contact)
(2) H (8-MOP) Pale yellow crystals 148-149 0.1 μM >100 μM >100 μM
(3) -N=N-NMe2 Yellow crystals 187-189 >100 μM >100 μM 20 μM
(4) -N=N-NEt2 Orange crystals 123-124 >100 μM >100 μM 6 μM
(5) -N=N-N(Me)(Et) Yellow crystals 145-147 >70 μM >100 μM 10 μM
(6) -N=N-N(Me)(nBu) Dark yellow crystals 66-67 4 μM >100 μM 7 μM
(7) -NH-CO-(4-N3-Ph) Light tan solid 185-187 33 μM >100 μM >300 μM
(8) -NH-CO-NH(CH2)2Cl White crystals 242-244 >100 μM >100 μM >300 μM
(9) -NHCOCH2Cl Beige crystals 270-272 40 μM 50 μM 4 μM
*

IC50 = concentration of psoralen inhibiting growth by 50%

#

All compounds had combustion analyses (C,H,N) within ± 0.3% of theoretical.