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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Endod. 2019 Feb;45(2):181–188. doi: 10.1016/j.joen.2018.10.007

Figure 4. Effect of YC-1 on wound healing in TLR2/IL-10-dKO mice.

Figure 4.

The effect of YC-1-mediated HIF-1 inhibition on wound healing in infected TLR2/IL-10-dKO mice was determined on day 21 post pulpal infection (n=4/group). YC-1-mediated inactivation of the HIF-1α pathway in this model was confirmed by 69–83% suppression of CP gene expression vs. control. (A and B) Mandibular molar region in YC-1-treated TLR2/IL-10-dKO on the sagittal (A) and, coronal plane. Broken line: center of first molar distal root. (C) H&E staining of YC-1 treated TLR2/IL-10-dKO. R: distal root, Scale bar: 300 μm (20X). (D and E) PBS-injected TLR2/IL-10-dKO control, on the sagittal (D) and coronal plane. (F) H&E staining of PBS treated TLR2/IL-10-dKO. In all samples, the level of inflammation was milder in YC-1-treated mice compared to controls. R: first molar distal root, Scale bar: 300 μm, 20X magnification.