Skip to main content
. 2018 Dec 24;3(2):427–445. doi: 10.1210/js.2018-00318

Figure 1.

Figure 1.

Neuronal SIRT1 caused glucose intolerance in mice. Data for N-MUT mice are shown in red, in white for WT littermates, and green for N-OX mice in green. For (A–D), Two-way ANOVA indicated significant genotype and time effects (P < 0.0001) but no interaction. (A) Body weights for male mice from 3 to 13 wk of age (n = 13 for N-MUT; n = 48 for WT; n = 24 for N-OX). Inset shows final body weight at 8 to 9 mo. (B) Body weights for female mice from 3 to 13 wk of age (n = 10 for N-MUT; n = 44 for WT; n = 20 for N-OX). Inset shows final body weight at 8 to 9 mo. (C) Glucose tolerance testing in male mice at 3 mo of age (n = 8 for N-OX; n = 16 for WT; n = 4 for N-MUT). Two-way ANOVA indicated significant interaction effect (P = 0.005). Inset shows AUC data. (D) Glucose tolerance testing in female mice at 3 mo of age (n = 9 for N-OX; n = 16 for WT; n = 6 for N-MUT). Inset shows AUC data. (E) Insulin tolerance testing in male mice at 3 mo of age (n = 9 for N-OX; n = 16 for WT; n = 6 for N-MUT). (F) Insulin tolerance testing in female mice at 3 mo of age (n = 10 for N-OX; n = 16 for WT; n = 6 for N-MUT). (E, F) Two-way ANOVA indicated significant genotype and time effects (P < 0.001 and P < 0.0001, respectively) but no interaction. (G) Daily food intake over 10 wk for male mice (n = 3 for N-MUT; n = 12 for WT; n = 4 for N-OX). (H) Daily food intake over 10 wk for female mice (n = 6 for N-MUT; n = 11 for WT; n = 5 for N-OX). (I) Fasting blood glucose data of male mice (n = 17 for N-OX; n = 32 for WT; n = 8 for N-MUT). (J) Fasting blood glucose data of female mice (n = 20 for N-OX; n = 32 for WT; n = 4 for N-MUT). (K) Fasting insulin data of male mice (n = 6 for N-MUT; n = 14 for WT; n = 6 for N-OX). (L) Fasting insulin data of female mice (n = 6 for N-MUT; n = 12 for WT; n = 6 for N-OX). (M) Fasting leptin data of male mice (n = 6 for N-MUT; n = 14 for WT; n = 6 for N-OX). (N) Fasting leptin data of female mice (n = 6 for N-MUT; n = 12 for WT; n = 6 for N-OX). Data are reported as mean ± SEM. *P < 0.05, **P < 0.01, *P < 0.001, and ****P < 0.0001 vs WT or as indicated. AUC, area under the curve.