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. 2018 Dec 24;3(2):427–445. doi: 10.1210/js.2018-00318

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Copyright © 2019 Endocrine Society

This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Figure 7. — Metabolic cage assessment of N-OX mice. Data of WT mice (n = 6) are shown in black and of N-OX mice (n = 6) in green. Graphs show diurnal patterns over 24 h measured per 13-min interval for the measures indicated by the y-axis labels. Horizontal black bar indicates period of lights off (6:00 pm to 6:00 am). (A) Ambulatory activity counts. (B) Rearing activity counts. (C) VO₂ consumption. (D) Respiratory exchange ratio. (E) Food intake. (F) Water intake. (G) Heat produced. (H) Cage temperature. Data are reported as mean ± SEM. In all cases, repeated measures ANOVA indicated a significant time effect (P < 0.0001). Ambulatory activity, rearing activity, VO₂, RER, and water intake were associated with significant genotype effects (P < 0.0001, P < 0.0001, P < 0.0001, P = 0.0004, and P = 0.04, respectively). *P < 0.05, **P < 0.01, by post hoc testing. RER, respiratory exchange ratio; Temp, temperature; VO₂, oxygen consumption.