Table 1:

Composition of 5-FUChnps containing different amounts of chitosan and poloxamer-188

Formulation	5-FU (% w/v)	ChiL (% w/v)	ChiM (% w/v)	P-188 (% w/v)	TPP (% w/v)	Hase (% w/v)
1	20	-	0.4	1.0	0.3	0.5
2	30	-	0.4	1.0	0.3	0.5
3	40	-	0.4	1.0	0.3	0.5
4	50	-	0.4	1.0	0.3	0.5
5	20	0.4	-	1.0	0.3	0.5
6	30	0.4	-	1.0	0.3	0.5
7	40	0.4	-	1.0	0.3	0.5
8	50	0.4	-	1.0	0.3	0.5
9	20	-	0.4	1.5	0.3	0.5
10	30	-	0.4	1.5	0.3	0.5
11	40	-	0.4	1.5	0.3	0.5
12	50	-	0.4	1.5	0.3	0.5
13	20	0.4	-	1.5	0.3	0.5
14	30	0.4	-	1.5	0.3	0.5
15	40	0.4	-	1.5	0.3	0.5
16	50	0.4	-	1.5	0.3	0.5

5FU = 5-Flurouracil, Chi_L= low molecular weight, Chi_M=medium molecular weight chitosan, chitosan, P-188 = poloxamer-188, TPP = sodium tripolphosphate. Hase: Hyaluronidase