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Current model for the structure of IαI and its conversion to HC(SHAP)–HA matrices (23). The schematic structure of IαI family molecules and the SHAP-HA complex are shown in a, and the structures of the HCs and bikunin are shown in b. The electron micrograph shows the globular domains (arrowheads) and stem structures (arrows) of HCs that are bound to the hyaluronan molecules. The ester linkage between hyaluronan and the aspartate in HC is shown in c.
