Figure 1.

COX and POX reactions catalyzed by PGHSs. There are two PGHS isoforms that are commonly known as cyclooxygenases-1 and -2 (COX-1 and COX-2). Downstream PG products are formed from PGH₂ via different synthases. The COX activity of the two COX isoforms is inhibited differently by nsNSAIDs, such as ibuprofen, naproxen, and aspirin, and by COX-2–selective inhibitors called coxibs, such as celecoxib and rofecoxib, and a variety of Fas, including ω-3 fish oil FAs such as EPA and DHA. This figure and the legend are modified from ASBMB Today (http://www.asbmb.org/asbmbtoday/201508/LipidNews/).