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. Author manuscript; available in PMC: 2019 Feb 6.
Published in final edited form as: Chem Soc Rev. 2017 Jul 31;46(15):4661–4708. doi: 10.1039/c6cs00542j

Fig. 5.

Fig. 5

(a) Individual microscopic events underlying the aggregation mechanisms of amyloids. (b) The identification of the aggregation mechanisms and the specific intervention on targeted microscopic reactions are fundamental for the rational design of tailored functions. This concept is illustrated here with the example of the peptide Aβ1–42, for which the generation of particularly active species can be modulated by inhibiting different microscopic steps. Reprinted with permission from ref. 225. Copyright 2015 Nature Publishing Group.