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. Author manuscript; available in PMC: 2019 Feb 6.
Published in final edited form as: Chem Soc Rev. 2017 Jul 31;46(15):4661–4708. doi: 10.1039/c6cs00542j

Table 1. Summary of the types, species, length scales and formation conditions of amyloid nanostructures.

Amyloid type Species Length scale Assembly condition Ref.
Oligomers Lysozyme Monomer to fibril pH 3, 70 °C 257
Cyclic peptide Monomer, dimer, tetramer 20 mM PBS, pH 7 254
KCKCLGDVIEV 6-mers/2.2 nm 262
β2-Microglobulin pH 7.5, 20 mM Tris 263
0D
NPs PrP 17–27 nm Self-assembly 265
NPs Recom-PrP 20 nm Self-assembly 266
NPs 1–40 15–30 nm Self-aggregation 268
Sphere FFF-peptide 10–13 nm Self-assembly 269
Sphere 1–40 10–60 nm Membrane-assembly 270
Loop α-synu-A53T H = 2–4 nm, D = 23–55 nm Self-assembly 271
Loop ApoC-II H = 2.1 nm, W = 12 nm, D = 50–75 nm Self-aggregation in PBS buffer 272
Triangle ApoC-III D = 35–77 nm NaPi buffer 276
1D
Protofibril β-Lactoglobulin H = 3 nm, L = 500 nm pH 2, 90 °C, D2O 240
Protofibril 1–42 13–28 nm PBS, 37 °C 290
Protofibril α-synuclein L = 7.5, W = 2.5 nm HEPES, 37 °C 291
Helical fibril β-Lactoglobulin L = 0.5–15 μm, H = 2–6 nm pH 2, self-assembly 233
Fibril TTR105–115 H = 7–16 nm, L = 1–3 μm Acetone/water, pH 2 294
Ribbon ILQINS W = 63–87 nm, L = 5.57 μm pH 2, 90 °C 297
Ribbon β22AKLVFF W = 17.5 nm Self-assembly 293 and 298
Cofibril (FKFE)2 D = 8.2 ± 1.0 nm, L = a few 100 nm Self-assembly in water 299
Ribbon R3 W = 147 nm, L = a few μm Self-assembly in buffer 301
Ribbon hIAPP20–29 H = 7.4 nm, L = several 100 nm Self-assembly 303
Nanotube KI4K D = 80–160 nm, L = a few μm Self-assembly in water 311
Nanotube Zn8R4 D = 20–48 nm, L = a few μm Zn2+-Induced assembly 312
Nanotube FF, Boc-FF L = 10 μm 90 °C, H2O, assembly 313
Nanotube CPT-Sup35 D = 123 ± 28 nm, L = a few μm 1 : 1 MeCN/H2O 314
2D
Film Lysozyme A few mm Stacking 315
Film β-Lactoglobulin Adjustable Filtration 316
Film β-Lactoglobulin Adjustable Self-assembly at air–water interface 317
Nanosheet 16–22 H = 2.3 nm, W = 500 nm, L = a few μm Self-assembly 323
Sheet A6R Thick = 3 nm, L/W = a few 100 nm Self-assembly in solution 324
3D
Plaques 1–42 Several-100 μm Aggregation 331
Multilayer Ne-RGDFF-OH Hydrogel Assembly at pH 8/6.5 332
Microgels Lysozyme 2–60 μm Microdroplet 334