Table 2.
Fifteen models predicting risk of autism by main effects and interaction between CNV burden and average air pollution exposure spanning pregnancy through the first two years of life (n=305)a
| CNV Burden | Air Pollutant | CNV Burden | Air Pollutant | Interaction |
|---|---|---|---|---|
| Duplications | TRP | 1.51 (1.08–2.11) | 1.28 (0.98–1.70) | 0.95 (0.73–1.23) |
| NO2 | 1.48 (1.06–2.07) | 1.28 (0.99–1.67) | 0.94 (0.77–1.15) | |
| Ozone | 1.85 (1.25–2.73) | 1.20 (0.93–1.54) | 1.55 (1.09–2.21) | |
| PM10 | 1.46 (1.05–2.03) | 1.52 (1.16–2.01) | 0.93 (0.73–1.19) | |
| PM2.5 | 1.48 (1.06–2.05) | 1.48 (1.13–1.95) | 0.95 (0.72–1.24) | |
| Deletions | TRP | 1.16 (0.89–1.52) | 1.33 (1.00–1.76) | 0.81 (0.59–1.11) |
| NO2 | 1.13 (0.87–1.48) | 1.44 (1.07–1.95) | 0.96 (0.73–1.26) | |
| Ozone | 1.17 (0.90–1.52) | 1.05 (0.81–1.37) | 1.06 (0.83–1.36) | |
| PM10 | 1.15 (0.88–1.51) | 1.71 (1.26–2.32) | 0.98 (0.73–1.33) | |
| PM2.5 | 1.16 (0.89–1.51) | 1.62 (1.19–2.20) | 0.83 (0.61–1.13) | |
| Total | TRP | 1.68 (1.24–2.28) | 1.28 (0.99–1.66) | 0.88 (0.68–1.15) |
| NO2 | 1.61 (1.19–2.18) | 1.32 (1.01–1.73) | 0.92 (0.75–1.14) | |
| Ozone | 1.76 (1.30–2.39) | 1.08 (0.85–1.38) | 1.36 (1.01–1.81) | |
| PM10 | 1.67 (1.22–2.29) | 1.58 (1.20–2.07) | 0.87 (0.68–1.11) | |
| PM2.5 | 1.70 (1.23–2.33) | 1.50 (1.41–1.97) | 0.84 (0.65–1.08) |
a
CNV burden and regional pollution effects reflect risk of autism based on a 1 SD of the distribution, specifically per increase of 1,356,513 base pair of duplication burden, 17.7 ppb of TRP, 6.2 ppb of ozone, 5.7 ppb NO2, 6.2 ug/m3 PM10, 3.7 ug/m3 PM2.5
b
Models adjusted for maximum education level of parents, child’s sex and child’s ethnicity (based on ancestry informative markers in the genome)