Table 3. Association of PCSK9 loss-of-function variants and risk of serious infection and sepsis hospitalizations.

Serious infection risk estimated by Cox proportional hazards analysis. Odds of sepsis among serious infection hospitalizations estimated by logistic regression. CI = confidence interval, HR = hazard ratio, OR = odds ratio.

Serious Infection Hospitalizations (N = 10,924)	No. Events	No. Non-Events	Events Per 1,000 Person-Years (95%CI)	Crude HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 3 HR (95% CI)
PCSK9 variant present	14 (5.7%)	230 (94.3%)	9.8 (5.8–16.5)	0.82 (0.48–1.40)	0.84 (0.49–1.42)	0.68 (0.38–1.25)	0.83 (0.49–1.40)
PCSK9 variant absent	765 (7.2%)	9,915 (92.8%)	11.9 (11.1–12.8)	Ref.	Ref.	Ref.	Ref.
Total	779 (7.1%)	10,145 (92.9%)	11.9 (11.1–12.7)	-	-	-	-
Sepsis Within Serious Infection Hospitalizations (N = 779)	No. Events	No. Non-events	Events Per 1,000 Person-Years (95%CI)	Crude OR (95% CI)	Model 1 OR (95% CI)	Model 2 OR (95% CI)	Model 3 OR (95% CI)
PCSK9 variant present	11 (2.5%)	3 (0.9%)	N/A	3.28 (0.91–11.84)	3.34 (0.91–12.19)	7.31 (0.91–58.7)	3.22 (0.89–11.6)
PCSK9 variant absent	404 (97.4%)	361 (99.2%)	N/A	Ref.	Ref.	Ref.	Ref.
Total	415 (53.3%)	364 (46.7%)	N/A	-	-	-	-

Model 1. Adjusted for demographics, smoking, and alcohol use

Model 2. Adjusted for model 1 + comorbidities + biomarkers

Model 3. Adjusted for sepsis risk score categories