Table 2. In the absence of Ikaros, resting CD4 T cells up-regulate expression of pathways linked to the response to type I Interferons.

Results of GSEA analyses of microarray data for freshly isolated Ik^flox x dLck-Cre [Cre+] and Ik^flox (no Cre) [Cre] CD4 T cells. In total, 152 gene sets were significantly enriched in Cre+ relative to Cre- CD4 T cells (FDR q<0.25). Examples of enhanced biological processes, functions and pathways are shown. ES: Enrichment score; NES: Normalized enrichment score.

Gene Set Name	Gene Set Size	ES	NES	Nominal p value	FDR q value
Hallmark Interferon Alpha Response	87	0.63	2.23	<0.001	0.0033
Reactome Interferon Alpha Beta Signaling	39	0.73	2.25	<0.001	0.0055
GO Response to Type I Interferon	41	0.67	2.14	<0.001	0.0244
Reactome Interferon Signaling	115	0.55	2.06	<0.001	0.0349
GO Response to Interferon Alpha	16	0.78	2.04	<0.001	0.0358
Reactome RIG MDA5 Mediated Induction of IFN Alpha Beta Pathway	53	0.59	1.99	<0.001	0.0541
GO Response to Interferon Beta	20	0.72	1.94	<0.001	0.0756