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. Author manuscript; available in PMC: 2019 Oct 15.
Published in final edited form as: Eur J Pharm Sci. 2018 Aug 8;123:502–514. doi: 10.1016/j.ejps.2018.08.008

Fig. 1: Free Drug Theory.

Fig. 1:

According to free drug theory only free drug can reach the site of action or metabolism, and at steady state, the unbound drug concentration is the same on both sides of the membrane.