. Author manuscript; available in PMC: 2019 Oct 15.

Published in final edited form as: Eur J Pharm Sci. 2018 Aug 8;123:502–514. doi: 10.1016/j.ejps.2018.08.008

Table 1:

Equations Commonly Used for IVIVE

Model	Clearance Equation
Traditional Well-Stirred	$C L_{H} = \frac{Q_{H} \cdot f_{u, B} \cdot C L_{i n t, i n v i v o}}{Q_{H} + f_{u, B} \cdot C L_{i n t, i n v i v o}}$	(5)
Correction for binding in the incubation	$C L_{H} = \frac{Q_{H} \cdot (\frac{f_{u, B}}{f_{u, i n c}}) \cdot C L_{i n t, i n v i v o}}{Q_{H} + (\frac{f_{u, B}}{f_{u, i n c}}) \cdot C L_{i n t, i n v i v o}}$	(6)
Correction for pH gradient	$C L_{H} = \frac{Q_{H} \cdot f_{u, p} \cdot R_{B} \cdot C L_{i n t} \cdot F 1}{Q_{H} + f_{u, p} \cdot R_{B} \cdot C L_{i n t} \cdot F 1}$	(10)
Correction for pH gradient and PLR	$C L_{H} = \frac{Q_{H} \cdot C L_{i n t} \cdot R_{B} \cdot f_{u, p - a d j u s t e d} / f_{u, i n c}}{Q_{H} + \cdot C L_{i n t} \cdot R_{B} \cdot f_{u, p - a d j u s t e d} / f_{u, i n c}}$	(13)