Table II.
Univariate and multivariate analyses of overall survival in patients with colorectal cancer (Cox regression model).
| Factors | Univariate analysis
|
Multivariate analysis
|
||||
|---|---|---|---|---|---|---|
| RR | 95% CI | P-value | RR | 95% CI | P-value | |
| Age (≤65/>65 years) | 0.59 | 0.26-1.28 | 0.1855 | - | - | - |
| Sex (male/female) | 1.35 | 0.60-3.28 | 0.4769 | - | - | - |
| Histology grade (muc, por/tub1, tub2, pap) | 2.65 | 0.88-6.54 | 0.0778 | - | - | - |
| Depth of tumor invasion (T3, T4/Tis, T1, T2) | 11.8 | 3.50-73.4 | <0.0001a | 7.76 | 1.95 52.7 | 0.0021a |
| Lymph node metastasis (positive/negative) | 5.28 | 2.42-12.1 | <0.0001a | 2.84 | 1.10 8.30 | 0.0303a |
| Lymphatic invasion (positive/negative) | 3.34 | 1.27-11.5 | 0.0123a | 0.49 | 0.13 2.10 | 0.3138 |
| Venous invasion (positive/negative) | 5.13 | 2.32-11.8 | <0.0001a | 2.46 | 1.05 6.09 | 0.0389a |
| MAF1 expression (positive/negative) | 4.12 | 1.43-17.4 | 0.0062a | 1.94 | 0.64 8.43 | 0.2666 |
a
P<0.05. CI, confidence interval; MAF1, MAF1 homolog, negative regulator of RNA polymerase III; muc, mucinous adenocarcinoma; pap, papillary adenocarcinoma; por, poorly differentiated adenocarcinoma; RR, relative risk; Tis, tumor in situ; tub1, well differentiated tubular adenocarcinoma; tub2, moderately differentiated tubular adenocarcinoma.