Table III.
Univariate and multivariate analyses of overall survival in MSI cases using The Cancer Genome Atlas dataset (Cox regression model).
| Factor | Univariate analysis
|
Multivariate analysis
|
||||
|---|---|---|---|---|---|---|
| RR | 95% CI | P-value | RR | 95% CI | P-value | |
| Age (≤65/>65 years) | 0.33 | 0.05-1.19 | 0.0962 | - | - | - |
| Sex (male/female) | 0.24 | 0.06-0.76 | 0.0131a | 0.21 | 0.05 0.69 | 0.0079a |
| Depth of tumor invasion (T3, T4/T1, T2) | 3.21 | 0.65-58.2 | 0.1797 | - | - | - |
| Lymph node metastasis (negative/positive) | 0.82 | 0.30-2.61 | 0.7124 | - | - | - |
| MAF1 expression (low/high) | 0.25 | 0.07-0.70 | 0.0075a | 0.22 | 0.06 0.64 | 0.0046a |
a
P<0.05. CI, confidence interval; MAF1, MAF1 homolog, negative regulator of RNA polymerase III; RR, relative risk; Tis, tumor in situ.