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. 2019 Jan 8;54(3):845–858. doi: 10.3892/ijo.2019.4680

Figure 2.

Figure 2

miR-3664-5P inhibits GC cell proliferation in vitro. (A) Following transfection with miR-3664-5P mimics or inhibitors, the expression of miR-3664-5P was significantly upregulated or downregulated, respectively, in the MKN45 and MGC803 cell lines. MGC803 was transfected with miR-3664-5P overexpres-sion lentivirus for in vivo assays. miR-3664-5P levels were determined by reverse transcription-quantitative polymerase chain reaction. (B) EdU, (C) Cell Counting Kit-8 and (D) plate colony assays were performed to detect the viability of GC cell lines (magnification, x200). miR-3664-5P upregulation inhibited and miR-3664-5P downregulation promoted the proliferation of GC cells. Data are presented as the mean ± standard error of the mean, from three independent experiments. **P<0.01 and ***P<0.001 vs. the corresponding NC. NC, negative control; miR-inhibitor-NC, cells transfected with the negative control of the miR-3664-5P inhibitor; miR-inhibitors, cells transfected with miR-3664-5P inhibitors; miR-mimics-NC, cells transfected with the negative control of the miR-3664-5P mimics; miR-mimics, cells transfected with miR-3664-5P mimics; miR, microRNA; GC, gastric cancer; LV, lentivirus.