Table II.
Univariate and multivariate survival analyses evaluating miR-3664-5P expression influencing overall survival in gastric cancer (n=100).
| Variables | Univariate
|
Multivariate analysis
|
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Sex | 0.427 | NA | ||
| Male | 1 | |||
| Female | 0.770 (0.404-1.468) | |||
| Age, years | 0.389 | NA | ||
| ≤50 | 1 | |||
| >50 | 0.753 (0.395-1.436) | |||
| Differentiation | 0.010b | 0.013a | ||
| Well/ moderately | 1 | 1 | ||
| Poor | 2.176 (1.207-3.923) | 2.201 (1.178-4.113) | ||
| Clinical stage | 0.188 | NA | ||
| I-II | 1 | |||
| III-IV | 1.501 (0.820-2.750) | |||
| Tumor size, cm | 0.041a | 0.170 | ||
| ≤3.5 | 1 | 1 | ||
| >3.5 | 1.867 (1.027-3.396) | 1.546 (0.829-2.883) | ||
| Lymph node metastasis | 0.009b | 0.003b | ||
| No | 1 | 1 | ||
| Yes | 2.252 (1.225-4.139) | 2.601 (1.379-4.907) | ||
| T classification | 0.372 | NA | ||
| T1-T2 | 1 | |||
| T3-T4 | 1.306 (0.726-2.350) | |||
| miR-3664-5P expression | 0.001c | 0.029a | ||
| Low | 1 | 1 | ||
| High | 0.360 (0.195-0.666) | 0.492 (0.260-0.931) | ||
All of the results were adjusted using Cox proportional hazards models for differentiation, tumor size, lymph node metastasis and miR-3664-5P expression.
a
P<0.05;
b
P<0.01;
c
P<0.001. NA, not adopted; HR, hazards ratio; CI, confidence interval; miR, microRNA.