Table III.
Variables | Univariate
|
Multivariate analysis
|
||
---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Sex | 0.880 | NA | ||
Male | 1 | |||
Female | 0.945 (0.458-1.952) | |||
Age, years | 0.362 | NA | ||
≤50 | 1 | |||
>50 | 0.700 (0.325-1.507) | |||
Differentiation | 0.006b | 0.024a | ||
Well/moderately | 1 | 1 | ||
Poor | 2.625 (1.310-5.260) | 2.257 (1.114-4.573) | ||
Clinical stage | 0.536 | NA | ||
I-II | 1 | |||
III-IV | 1.245 (0.622-2.493) | |||
Tumor size, cm | 0.163 | NA | ||
≤3.5 | 1 | |||
>3.5 | 1.641 (0.818-3.288) | |||
Lymph node metastasis | 0.150 | NA | ||
No | 1 | |||
Yes | 1.663 (0.832-3.326) | |||
T classification | 0.790 | NA | ||
T1-T2 | 1 | |||
T3-T4 | 1.009 (0.550-2.196) | |||
miR-3664-5P expression | 0.003b | 0.010b | ||
Low | 1 | 1 | ||
High | 0.334 (0.163-0.686) | 0.380 (0.183-0.791) |
All of the results were adjusted using Cox proportional hazards models for differentiation and miR-3664-5P expression.
P<0.05;
P<0.01. NA, not adopted; HR, hazards ratio; CI, confidence interval; miR, microRNA.