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. 2018 Dec 12;54(3):916–928. doi: 10.3892/ijo.2018.4665

Figure 5.

Figure 5

FoxM1 knockdown abolishes H. pyloriCagA+/P+-induced EMT in SGC-7901 cells. (A) FoxM1 mRNA expression levels in cells transfected with si-NC or si-FoxM1. (B) FoxM1 protein expression was detected following transfection with si-FoxM1. (C) Protein expression levels of EMT markers, E-cadherin, Vimentin and α-SMA, in SGC-7901 cells transfected with si-NC or si-FoxM1, and infected with H. pyloriCagA+/P+. Relative mRNA expression levels of (D) E-cadherin, (E) Vimentin and (F) α-SMA in SGC-7901 cells, as determined by reverse transcription-quantitative polymerase chain reaction analysis. *P<0.05 vs. the si-NC group; #P<0.05 vs. the control group; $P<0.05. vs. the H. pyloriCagA+/P+ group. α-SMA, α-smooth muscle actin; CagA, cytotoxin-associated gene A; EMT, epithelial-mesenchymal transition; H. pyloriCagA−, CagA-negative H. pylori; H. pyloriCagA+/P−, CagA-positive and PBP1A mutation-negative H. pylori; H. pyloriCagA+/P+, CagA- and PBP1A mutation-positive H. pylori; FoxM1, Forkhead box M1; H. pylori, Helicobacter pylori; NC, negative control; si, small interfering RNA.